6-Chlorohexanol stands out as a specialized organohalide, featuring both an alcohol and a chlorine group along its carbon chain. Chemists often point to its formula, C6H13ClO, when talking about its unique place among chlorinated alcohol compounds. By connecting a chlorine atom to the sixth carbon of the hexanol backbone, researchers produce a chemical with properties that make it useful for a variety of applications. Its structure sets the tone for how it behaves in the lab and, more importantly, in industrial settings. That one chlorine atom not only changes the molecule’s reactivity but also plays a significant role in its physical appearance and handling requirements.
Many chemical suppliers offer 6-Chlorohexanol as a colorless liquid at room temperature, though some batches may appear as flaky solids or crystalline powders depending on storage conditions and purity. The substance has a distinct, almost faintly sweet odor typical of many chloroalcohols and doesn't easily evaporate into the air under ordinary laboratory conditions. Its density registers at approximately 1.02 grams per cubic centimeter, just a bit above water, meaning it settles quickly if spilled or placed in a less dense solvent. Researchers and plant operators find it manageable in bulk storage, particularly in well-sealed containers that prevent moisture ingress or unnecessary exposure to air.
Examining the structure of 6-Chlorohexanol, it contains a six-carbon alkyl chain capped by a hydroxyl group on one end and a chlorine atom on the other. This layout not only determines its reactivity but also its use in various synthetic schemes. The compound participates in substitution and elimination reactions, driven both by the electrophilic chlorine and the nucleophilic alcohol group. The formula C6H13ClO translates into a molar mass of about 136.62 g/mol, giving chemists a clear sense of dosing and process requirements in laboratory and industrial syntheses.
Industries often turn to 6-Chlorohexanol as a raw material for more complex molecules. The chlorinated alcohol serves as a building block in the production of surfactants, plasticizers, pharmaceuticals, and specialty solvents. In my experience working with research and development teams, 6-Chlorohexanol often finds its way into projects that demand a balance between solubility and reactivity. Its structure allows developers to append larger, function-driven groups to the six-carbon backbone, making the molecule adaptable for different end uses. Custom synthesis shops find demand for it in kilogram to ton scales, especially from pharmaceutical companies looking to build new intermediates for drug candidates that rely on controlled placement of both hydroxyl and halogen functionalities.
Storing 6-Chlorohexanol calls for a bit of respect. The liquid keeps well in tightly sealed glass or HDPE containers, away from open flames or oxidizing agents. Although not classified as highly volatile, operators still treat it as a chemical hazard because both chloro compounds and alcohols can irritate the skin and mucous membranes. My daily work with similar compounds means handling gloves, safety glasses, and fume hoods remain standard procedure. In the event of a spill, absorbent material and proper ventilation help reduce immediate risks. Material Safety Data Sheet (MSDS) guidance highlights the need for good airflow, protective gear, and prompt washing after skin contact. For facilities managing tonnage volumes, fire suppression and environmental controls for water run-off become key safety priorities.
Shipping and international trade regulations classify 6-Chlorohexanol under HS Code 29055990, which covers other saturated acyclic monohydric alcohols and derivatives. Depending on local chemical control laws—including Europe’s REACH system or the US EPA’s TSCA Inventory—companies importing or exporting this product may face notification requirements and product registration. Chemical buyers should confirm they meet transportation labeling rules, particularly if volumes exceed thresholds set by international safety agencies.
Hazard assessment on 6-Chlorohexanol lists it as a harmful substance by inhalation, ingestion, or skin absorption. Chronic exposure risks are not fully documented, but anyone working in manufacturing or laboratory spaces needs to understand its toxicity profile. Risk phrases indicate it may cause damage to target organs through prolonged or repeated contact, and while accident literature remains limited, taking the compound for granted is not recommended. Waste management teams prepare for safe disposal by avoiding sewer releases and employing designated chemical waste streams. Studies suggest its breakdown in the environment can release chloride ions and small organic fragments, so avoiding accidental releases protects both on-site personnel and surrounding ecosystems.
Quality control labs check for purity (usually above 97%) using gas chromatography and nuclear magnetic resonance, making sure residual solvents, water, and byproducts remain below contractually specified levels. To ensure reliable performance, consistency in density, refractive index, and melting point measurements play a central role in batch acceptance—a lesson learned from years of troubleshooting downstream product variations caused by off-spec intermediates. Customers expect documentation of chemical analysis and impurity profiles with every lot, which protects against unexpected surprises during scale-up or formulation.
Pressure for improved chemical safety and transparency means suppliers and users alike take greater care in tracing product origins and documenting handling practices. Adoption of closed transfer systems, better training for chemical handlers, and clear communication with emergency responders address potential hazards well before incidents occur. Supply chain audits, regular product testing, and clear storage procedures make a noticeable difference in plant reliability and worker safety. In my work, a shift toward greener solvents and alternatives puts 6-Chlorohexanol under review, yet its role in many essential syntheses ensures demand persists, pushing researchers to explore safer, more efficient ways to handle this and similar chlorinated intermediates.
