Product Name: Ketoprofen Nitrile (KPN)
Chemical Family: Nonsteroidal anti-inflammatory derivative
Recommended Uses: Pharmaceutical intermediate, Research chemical
Supplier Details: Manufacturer or distributor address, phone number, emergency phone number
Synonyms: 2-(3-Benzoylphenyl)propionitrile, KPN
CAS Number: Contact manufacturer for accurate identification
Product Code: Internal tracking or batch number
GHS Classification: Acute toxicity (oral), Skin corrosion/irritation, Eye damage/irritation, Specific target organ toxicity (single exposure)
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause respiratory irritation, harmful if swallowed
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Avoid breathing dust, wear protective gloves/clothing/eye protection, wash thoroughly after handling
Routes of Exposure: Inhalation, ingestion, skin or eye contact
Target Organs: Liver, kidneys, gastrointestinal tract
Symptoms: Nausea, headache, dizziness, irritation to mucous membranes
Chemical Name: Ketoprofen Nitrile
Formula: C16H13NO
Concentration: Pure substance
Impurities: Minor residual solvents or catalyst traces possible from manufacturing process
Other Identifiers: Contact supplier for full ingredient disclosure if used in mixture
Inhalation: Remove source of exposure, relocate to fresh air, support breathing if needed, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin immediately with plenty of water for at least fifteen minutes, seek medical attention for irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek prompt medical consultation
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical advice
Important Symptoms: Respiratory discomfort, persistent skin/eye irritation, gastrointestinal distress
Notes for Doctors: Treat symptomatically, consider possible exposure to nitrile-containing drugs and monitor for delayed effects
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, alcohol-resistant foam
Specific Hazards During Fire: Emits toxic fumes of nitrogen oxides, carbon monoxide, and other organic compounds on combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full personal protective gear
Hazardous Combustion Products: Incomplete combustion yields toxic gases, particularly under oxygen-deficient conditions
Fire-Fighting Instructions: Isolate area, contain runoff, use water spray to cool containers, avoid direct stream on material
Explosion Risks: Dust may form explosive mixtures with air under certain circumstances
Personal Precautions: Evacuate unnecessary personnel, use appropriate PPE including gloves, goggles, and dust mask
Spill Cleanup Methods: Absorb spill using inert materials such as dry sand or earth, scoop up and place in suitable container for disposal
Environmental Precautions: Prevent entry into drains, sewers, or waterways, notify authorities in case of large spills
Decontamination: Wash contaminated area with detergent and water, ventilate area to disperse any dust or vapors
Secondary Protection: Collect residues and dispose of in accordance with local regulations
Handling Precautions: Avoid formation of dust, do not inhale or ingest, handle in well-ventilated area, practice good industrial hygiene
Storage Conditions: Store in cool, dry, well-ventilated location, away from sources of ignition and incompatible substances
Packaging Materials: Use tightly sealed containers made of glass, HDPE, or compatible plastics
Segregation: Keep away from acids, strong oxidizing agents, bases
Loading Precautions: Prevent container falls, do not stack above recommended limits
Occupational Exposure Limits: No established exposure limit; minimize dust exposure
Engineering Controls: Use local exhaust or general ventilation, maintain workplace cleanliness
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash-proof safety goggles, lab coat or chemical protective clothing
Respiratory Protection: If ventilation inadequate or dust present, use NIOSH-approved dust respirator
Hygiene Measures: Wash hands before eating, drinking, or smoking, do not eat or drink in work area
Environmental Controls: Handle away from open drains or soil to prevent contamination
Physical State: White to off-white crystalline powder
Molecular Weight: Approximately 235 g/mol
Odor: Slight phenolic or medicinal odor
Melting Point: Reported around 94–99°C
Boiling Point: Not readily volatile at ambient conditions
Solubility: Very slightly soluble in water, soluble in organic solvents like ethanol, DMSO, acetone
pH: Not applicable in solid form
Flash Point: Data not available, but considered non-flammable as a solid
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): Estimated 3.2–3.8, indicative of moderate lipid solubility
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No significant reactivity under normal conditions
Hazardous Reactions: Contact with strong oxidizing agents, acids, or bases may result in hazardous decomposition
Conditions to Avoid: Heat, humidity, light, incompatible chemicals
Decomposition Products: Oxides of carbon, nitrogen, and cyanide compounds; can form harmful vapors on decomposition
Acute Toxicity: May cause harmful effects if swallowed, irritation to mucous membranes, skin, and eyes
Chronic Exposure: Repeated or prolonged contact may cause dermatitis, possible kidney or liver effects at high doses based on related substances
Carcinogenicity: No known human data; standard laboratory screening suggests low likelihood
Mutagenicity: Not classified as mutagenic based on available information
Reproductive Toxicity: Not specifically studied; NSAIDs may affect fetal development in animal studies
Sensitization: May cause skin sensitization in susceptible individuals
Routes of Entry: Inhalation, skin, ingestion, eye contact
Ecotoxicity: Toxic to aquatic life with long lasting effects if released in significant quantities
Persistence and Degradability: Limited data available, likely to persist in environment; degradation in soil/water may be slow
Bioaccumulation Potential: Risk of bioaccumulation in aquatic organisms due to moderate solubility in lipids
Mobility in Soil: Tends to bind to organic matter; groundwater contamination unlikely at small-scale use, but risks increase with large spills
Other Adverse Effects: Monitor effluent from manufacturing or disposal operations to prevent environmental discharge, avoid release directly into water systems
Waste Disposal Methods: Collect solid waste in sealable containers, dispose of as hazardous waste according to local, regional, or national regulations
Container Disposal: Rinse empty packaging thoroughly, render containers unusable, hand over to appointed waste contractor
Incineration: Allowed in licensed facility capable of safe combustion at high temperature to minimize toxic emissions
Sewage Disposal: Prohibited; do not release into municipal wastewater systems
Precautions: Document disposal, retain records as required by regulatory authorities
UN Number: Not assigned unless shipped in bulk quantities
Shipping Name: Ketoprofen Nitrile or Pharmaceutical Intermediate
Transport Hazard Class: Not classified as dangerous good under most international transport regulations
Packing Group: Not determined
Special Precautions for Transport: Protect from physical damage and moisture during transport, keep in original packaging
Labeling Requirements: Ensure correct labeling for chemical shipments; include hazard warnings and emergency information
Reach Status: Consult supplier for registration or pre-registration status within the EU
OSHA Hazard Communication: Chemical classified as hazardous per US OSHA criteria
TSCA Status: Check inventory listings for US compliance
Other National Inventory Status: Verify on country-specific chemical lists
Labeling: Conform to GHS/CLP requirements on product packaging
Workplace Restrictions: Adhere to all workplace safety and health standards for chemical agents
Restrictions on Use: Not intended for consumer use; for professional/laboratory application only
Additional Information: Always follow local, national, and international regulatory guidelines for storage, use, and disposal
