Product Name: Ketoprofen
Chemical Name: 2-(3-benzoylphenyl)propionic acid
Recommended Use: Pharmaceutical, laboratory chemical
CAS Number: 22071-15-4
Manufacturer: Major drug producers and pharmaceutical labs
Emergency Contact Number: Refer to local or national Poison Control Helpline
Synonyms: Orudis, Oruvail, Ketum, Fastum
Molecular Formula: C16H14O3
Molecular Weight: 254.28 g/mol
Supplier: Company supplying active pharmaceutical ingredients or research chemicals
GHS Classification: Acute Toxicity (Oral), Eye Irritation, Skin Irritation
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause an allergic skin reaction, harmful if swallowed, can trigger respiratory tract irritation
Precautionary Statements: Wash hands thoroughly after handling, avoid breathing dust or fumes, use protective gear including gloves and goggles
Symptoms of Exposure: Eye damage, rash, nausea, dizziness, stomach pain, breathing difficulty
Emergency Overview: White or almost white crystalline powder with little odor, direct contact can quickly irritate skin, mucous membranes, or eyes
Chemical Name: Ketoprofen
Synonyms: 2-(3-benzoylphenyl)propionic acid, Orudis, Oruvail
CAS Number: 22071-15-4
Concentration: >99% pure in raw material form
Impurities: Trace solvents from synthesis, residual cleaning agents rarely exceed 0.1%
Inhalation: Move to fresh air immediately, loosen any tight clothing, provide oxygen support if breathing is labored, seek medical advice for persistent symptoms
Skin Contact: Wash area with plenty of water and mild soap, remove contaminated clothing, monitor for redness or swelling, report persistent irritation to a doctor
Eye Contact: Rinse eyes with low-pressure water stream for at least 15 minutes, skip rubbing to avoid further irritation, seek medical evaluation for blurred vision or ongoing discomfort
Ingestion: Rinse mouth, drink a moderate amount of water, do not induce vomiting without medical input, contact a poison center or physician right away
Note to Physicians: Treat symptomatically, monitor for GI bleeding, allergic response, or respiratory distress
Suitable Extinguishing Media: Use dry chemical, CO2, foam, or water spray
Specific Hazards: Combustion may produce acrid smoke, carbon monoxide, carbon dioxide, or other toxic vapors
Firefighting Instructions: Wear self-contained breathing apparatus and full protective suit, avoid inhaling fumes
Protective Equipment: Insulated gloves, heavy-duty boots, face shield, flame-resistant uniform
Special Risks: Dust can form explosive mixtures with air, so avoid using high-pressure streams that could disperse powder into the air
Personal Precautions: Prevent dust cloud formation, ventilate area well, keep unprotected personnel away
Environmental Precautions: Block entry into drains, soil, or surface water, contain spill with absorptive material
Cleanup Methods: Collect powder using a vacuum with HEPA filter, transfer to a labeled waste container, wash spill area with soapy water after material is removed
Protective Equipment: Gloves, goggles, laboratory coat, approved mask
Disposal: Place residues in suitable, closable disposal containers marked hazardous
Handling: Avoid generating dust, work in well-ventilated areas or fume hoods, wear gloves and safety glasses, never eat or drink in workspace
Storage Conditions: Store in tightly closed original container, keep in a cool, dry, well-ventilated place, separate from incompatible materials such as oxidizers or strong acids
Incompatible Materials: Strong oxidizing agents, strong bases, strong acids
Special Storage Requirements: Clearly label shelves and containers, maintain humidity below 60%, lock storage for bulk quantities
Occupational Exposure Limits: No official OSHA, ACGIH, NIOSH exposure limits currently published—practice strict industrial hygiene
Engineering Controls: Use local exhaust or general room ventilation, lab fume hoods reduce risk
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat, dust mask or particulate respirator explained by risk assessment
Hygiene Measures: Wash hands and any exposed skin before breaks, after using material, ensure eyewash stations and emergency showers are available in work area
Other Protective Measures: Wear closed-toe shoes, avoid touching face during work, segregate work clothing for laundering
Appearance: White or almost white crystalline powder
Odor: Faint, not strong-smelling
Odor Threshold: Not available
pH: 3-4 (1% aqueous solution)
Melting Point / Freezing Point: 94-97°C
Boiling Point / Range: Decomposes before boiling
Flash Point: Nearly 185°C (closed cup method)
Evaporation Rate: Not relevant (solid at room temperature)
Flammability: Not classified as highly flammable, can catch fire under strong ignition
Vapor Pressure: Negligible at 25°C
Vapor Density: Not applicable
Solubility: Poorly soluble in water, easily dissolved in ethanol, acetone, chloroform
Partition Coefficient (Log Kow): Approximately 3.1
Auto-ignition Temperature: Not available
Decomposition Temperature: >200°C
Viscosity: Not applicable
Molecular Weight: 254.28 g/mol
Chemical Stability: Remains stable under normal ambient conditions
Possibility of Hazardous Reactions: Risk of dust explosions in air if large quantities dispersed
Conditions to Avoid: High heat, flames, sparks, sources of ignition, extended exposure to sunlight
Incompatible Materials: Strong oxidizers, bases, acids, reactive metals
Hazardous Decomposition Products: Forms carbon monoxide, carbon dioxide, acrid or irritating smoke if burned or heated strongly
Polymerization: Does not occur under normal handling
Acute Toxicity (Oral): LD50 (rat): about 360 mg/kg
Acute Toxicity (Dermal): Data not clearly established in humans
Acute Toxicity (Inhalation): Data limited, may cause respiratory irritation
Skin Corrosion/Irritation: Causes skin irritation and sensitization in susceptible individuals
Serious Eye Damage/Irritation: Triggers severe discomfort, redness, and watering
Respiratory or Skin Sensitization: Allergenic responses possible in workers with repeat or prolonged exposure
Mutagenicity: No strong data linking ketoprofen to genetic mutations
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: Risk of fetal harm if ingested during pregnancy, NSAIDs in general should be avoided during late term
Other Effects: Long-term use can lead to GI irritation, ulceration, or kidney effects, especially in the context of pharmaceutical use
Aquatic Toxicity: Harmful to aquatic organisms at higher concentrations, LC50 (Fish, 96 h): 3-10 mg/L
Persistence and Degradability: Degrades slowly in soil or water, can persist in the environment under low-oxygen conditions
Bioaccumulative Potential: Moderate bioaccumulation possible due to log Kow of 3.1
Mobility in Soil: Low mobility—binds to soil particles
Other Adverse Effects: Residues may reach water bodies through drug product disposal, wastewater, or manufacturing discharge, potentially affecting aquatic wildlife
Precautions: Avoid spilling or disposing product into sewage systems or open water sources
Waste Disposal Methods: Send waste to licensed hazardous waste facility, never pour down drain or mix with household trash
Contaminated Packaging: Treat as hazardous waste once empty, rinse to remove residues only as directed by local law
Legal Requirements: Comply with national or regional hazardous waste guidelines, obtain manifest or documentation if transporting large volumes
Sewage Disposal Restrictions: Prevent entry into municipal wastewater treatment flows or storm water drains
UN Number: Not classified as hazardous for transport in most jurisdictions
Proper Shipping Name: Ketoprofen
Transport Hazard Class: Not regulated under ADR, IMDG, IATA codes for most smaller amounts
Packaging Requirements: Use leak-proof containers, protective outer carton for bulk shipments
Special Precautions: Keep away from food, drugs, and animal feedstuffs during transit, ensure drivers and handlers are aware of potential hazards
Emergency Response: Provide safety sheet and instructions with shipment in event of spill or exposure
US Federal Regulations: Not listed by OSHA as hazardous, subject to FDA controls as a drug ingredient, EPA monitoring requirements for pharmaceutical discharges
International Regulations: Controlled under country-specific pharmaceutical and chemical regulations, included in WHO Essential Medicines List
Inventory Listings: Included in inventories such as TSCA (Toxic Substances Control Act), EINECS/ELINCS (EU), and others
Right to Know: Information available for workplace disclosure in many states and countries
Labelling: Product label must carry warnings about risks, required PPE, and emergency contacts
User Restrictions: For laboratory and industrial use only unless distributed as regulated finished pharmaceutical product
