Product Name: Hydrazide
Synonyms: Hydrazinecarboxamide, Hydrazinoformamide
Chemical Formula: CH4N2O
CAS Number: 123-26-2
Recommended Use: Laboratory chemical, intermediate for pharmaceuticals, specialty chemicals production
Manufacturer Information: Manufacturer address, emergency contact number, email for technical support
Emergency Telephone: Available 24/7 for chemical emergencies involving exposure, fire, or environmental release
GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin corrosion/irritation, Serious eye damage, Carcinogenicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin or inhaled; may cause cancer; causes skin and eye irritation
Pictograms: Skull and crossbones, health hazard, exclamation mark
Precautionary Statements: Avoid breathing dust/vapor/mist; wash skin thoroughly; wear protective gloves, eye and face protection; handle in a fume hood; avoid all contact with incompatible materials
Chemical Name: Hydrazide
Concentration: 100% (pure substance)
Impurities: Trace-level residuals from manufacturing, quality standards limit heavy metals and other potential contaminants
Formula: CH4N2O
Molecular Weight: 60.05 g/mol
Descriptors: White crystalline solid or powder; slight ammonia-like odor
Inhalation: Move person to fresh air; support breathing as needed; call physician and seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing; wash exposed skin with plenty of soap and water for at least 15 minutes; seek medical advice
Eye Contact: Rinse eyes gently with water for at least 15 minutes; remove contact lenses if present and easy to do; continue rinsing and seek immediate medical attention
Ingestion: Rinse mouth with water; do not attempt to induce vomiting; keep airway clear; seek immediate medical attention
Most Important Symptoms: Irritation, vomiting, headache, nausea, respiratory or neurological effects—periodic observation and medical monitoring recommended after exposure
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide for small fires
Unsuitable Media: Avoid high-pressure water jets that may spread chemical
Specific Hazards: Produces irritating, toxic fumes (nitrogen oxides, ammonia) when burned
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective gear
Special Procedures: Evacuate area, cool fire-exposed containers, stay upwind of fire; avoid runoff to sewers or waterways
Personal Precautions: Evacuate unnecessary personnel; provide adequate ventilation; avoid breathing vapors and direct skin or eye contact
Protective Equipment: Use chemical-resistant gloves, lab coats, goggles, and a NIOSH-approved respirator as appropriate
Environmental Precautions: Prevent spilled material from entering drains, soil, or surface water; notify authorities if contamination occurs
Clean-up Methods: Absorb spill with inert material (sand, earth, vermiculite); sweep up and place in a labeled disposal container; decontaminate area with suitable solution and ensure safe disposal
Handling: Work in closed systems or well-ventilated areas; avoid exposure to vapors, dust, and direct contact; never eat, drink, or smoke while handling
Storage: Store in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials (oxidizers, acids); protect containers from physical damage, moisture, and direct sunlight
Incompatibilities: Avoid storing near strong acids, oxidizing agents; keep away from ignition sources
Special Precautions: Label all storage areas and containers; maintain up-to-date safety and first-aid equipment nearby
Exposure Limits: OSHA PEL: 0.2 ppm (ceiling); ACGIH TLV: 0.01 ppm (TWA)
Engineering Controls: Use local exhaust ventilation, enclose processes, provide eyewash stations and showers
Personal Protection: Chemical-resistant gloves, safety goggles, lab coats or chemical aprons, and, for higher-risk tasks, NIOSH-approved respirator
Hygiene Measures: Wash hands after handling and before breaks or meals; remove contaminated clothing and wash separately
Appearance: White to off-white crystalline powder
Odor: Ammonia-like, slightly acrid
Odor Threshold: Low; detectable at low concentration
pH Value: Neutral in aqueous solution
Melting Point: 150–160°C
Boiling Point: Decomposes before boiling
Flash Point: Not flammable under normal conditions
Flammability: Not easily ignited; can burn if exposed to intense heat
Vapor Pressure: Low at 20°C
Solubility: Soluble in water, ethanol
Density: 1.44 g/cm³
Partition Coefficient (log Pow): Not available
Autoignition Temperature: Not established
Decomposition Temperature: >160°C (degrades to nitrogen oxides, ammonia)
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Can react vigorously with strong oxidizers and acids
Hazardous Reactions: Decomposes on heating or in acidic/oxidizing environments, generating toxic gases
Incompatible Materials: Avoid contact with oxidizers, strong acids, metals, metal oxides
Hazardous Decomposition Products: Nitrogen oxides, ammonia, other toxic compounds depending on conditions
Acute Toxicity: Oral (rat) LD50: 55 mg/kg; can cause severe health effects at low doses
Skin: May cause irritation, dermatitis with repeated contact
Eyes: Severe irritation, risk of serious eye damage
Respiratory: May cause coughing, shortness of breath, chest pain
Chronic Effects: Suspected of causing cancer based on animal studies; possible liver and kidney damage from prolonged exposure
Other Effects: May cause sensitization of the respiratory system or skin with repeated exposure
Ecotoxicity: Toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment
Biodegradability: Not readily biodegradable; persists in aquatic environments
Bioaccumulation: Likelihood of bioaccumulation considered low
Mobility in Soil: High solubility in water increases potential for groundwater contamination
Other Adverse Effects: Environmental monitoring recommended where handled in bulk
Disposal Methods: Dispose of in accordance with local, regional, national, and international regulations; incineration in a chemical incinerator equipped with afterburner and scrubber preferred
Special Considerations: Do not discharge into drains, watercourses, or the environment; avoid contamination of soil and groundwater
Container Disposal: Triple-rinse empty containers prior to disposal; remove labels and render unusable before recycling or landfilling according to local requirements
UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains hydrazide)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II (substance presents medium risk)
Marine Pollutant: Yes
Special Precautions: Label and securely package; keep upright during transport to prevent leaks; provide emergency information sheet with shipment
OSHA: Classified as hazardous, regulation of safe handling and exposure limits
TSCA: Listed
SARA 313: Subject to reporting requirements
California Proposition 65: May contain chemicals known to the State of California to cause cancer
EU Regulations: Covered by REACH regulations; subject to restrictions for certain uses
International Listings: Listed in inventories for regulated chemicals in Canada, Japan, Australia
Workplace Labeling Requirements: Full GHS-compliant hazard labeling and safety instructions displayed in all handling and storage areas
Training: Required annual safety training and documentation for workers
