Histry Chem

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Dimethyl Sebacate (DMS): Evolution, Properties, Use, and Perspective

Historical Development

Dimethyl Sebacate (DMS) has a lineage that tracks back to the early days of synthetic polymers and specialty esters. Chemists in the twentieth century pushed for solutions to the rising demand for flexible, weather-resistant materials. DMS found relevance early, with sebacic acid itself seeing application as early as the First World War—originally as a corrosion inhibitor and later as a feedstock for nylon. Over decades, as industrial processes matured, production methods shifted from castor oil-based transformations to refined, high-yield syntheses using catalytic esterification. What impresses me about this timeline is how focused problem-solving brought DMS from obscurity into the toolkit of polymer and specialty chemical industries. Chemists leveraged every available lesson in organic synthesis — not to just produce larger volumes, but to achieve the consistency and purity that today’s sectors require. This mindset allowed DMS to grow from a scientific curiosity to a backbone material.

Product Overview

Dimethyl Sebacate stands out thanks to its role as a plasticizer, intermediate, and functional additive. It comes across as a colorless, oily liquid, virtually odourless, and mixes well with most common organic solvents. As a molecule, it offers a C10 dicarboxylic backbone linked to two methyl esters, which delivers flexibility to molecular design. Think of consumer goods that demand both durability and pliability: DMS shows up in the manufacture of plastic films, synthetic resins, and long-chain polyamides, among others. It also works quietly in personal care, pharmaceuticals, and even in the formulation of low-temperature-resistant plastics used in challenging environments. In practical terms, DMS acts like a lubricant at the chemical level, softening rigid polymers and boosting their resistance to brittleness and cracking. That means longer-lasting everyday products, less waste, and ultimately lower costs.

Physical & Chemical Properties

Anyone who’s handled DMS recognizes it by its clarity and liquid state at room temperature. Its melting point sits close to -1°C, while its boiling point hovers at 265°C. At standard conditions, density walks around 1.07 g/cm³. DMS dissolves in acetone, ether, and most alcohols, but avoids mixing with water. Its vapour pressure sits on the lower side, reducing unwanted evaporation during storage or processing. On the chemical front, its ester bonds invite reaction with strong bases and acids, but under ordinary use, it shows good stability toward hydrolysis. High flash points and low acute reactivity mean safe handling, as long as operations avoid open flames or high-heat contact. In the lab or on the production floor, these properties translate into a straightforward experience for those with basic chemical safety training.

Technical Specifications & Labeling

Producers of Dimethyl Sebacate typically ensure product purity above 99%, putting a spotlight on factors like acid value staying below 0.2 mg KOH/g and water content below 0.1%. Viscosity checks fall between 5.5-8.0 mPa·s at 25°C, while refractive indices tend to measure around 1.431-1.435. Rigorous testing not only keeps performance predictable but also aligns with standards set by organizations such as ASTM and ISO. Labeling requirements often match the strictest regional standards: clear identification of batch number, purity, hazard symbols, storage temperature range, and regulatory compliance statements for transportation. Based on my time in compliance work, these steps don’t simply tick boxes—they build trust for down-the-line users who need their raw materials to deliver on every order, every time.

Preparation Method

Dimethyl Sebacate production hinges on the esterification of sebacic acid with methanol. Producers rely on either direct acid-catalysis or, in modern plants, an automated continuous-flow reactor that boosts throughput and reduces waste. The sebacic acid usually originates from castor oil through controlled oxidation and decarboxylation — itself a multi-step, carefully balanced process. Methanol reacts with the acid in the presence of sulfuric acid or p-toluenesulfonic acid as catalyst, releasing water as a byproduct that gets removed through azeotropic distillation. Final purification typically runs through vacuum distillation, giving a high-purity product suitable for demanding applications. Look at factory workflow diagrams, and nearly every process step focuses on maximum yield, minimum impurity, and clean recovery of unused reactants. These productivity-driven strategies reflect the current focus on sustainability and process efficiency, especially as raw material costs inch up each year.

Chemical Reactions & Modifications

DMS wears its chemistry openly. Its ester groups react in transesterification, alcoholysis, or hydrolysis reactions—opening the door to wide modification possibilities. Reacting with glycols or polyamines gets you polyesters or polyamides, which eventually become engineering plastics or fibers with tailored flexibility and mechanical strength. In research, chemists often tweak DMS using selective hydrogenation, halogenation, or even partnership with bio-based starting materials. This adaptability keeps DMS central when formulating new copolymers or plasticizers in high-tech goods. My experience in R&D tells me such flexibility means fewer formulation changes downstream and greater freedom for innovation. These options help companies respond faster to changing regulatory or consumer demands. Even in more niche realms, like specialty coatings or high-barrier films, chemists have started fusing DMS with new functional groups, unlocking further improvements in barrier properties and environmental resilience.

Synonyms & Product Names

In catalogs or procurement software, Dimethyl Sebacate may show up as Sebacic Acid Dimethyl Ester, DMS, or Methyl Sebacate. Some suppliers brand it under trade names if they offer specific blends or grades—sometimes simply referred to as “Sebacate Methyl Ester.” These alternate names matter, especially when sourcing in global markets, since misidentification risks delays, regulatory slip-ups, or quality complaints. It pays to know your synonyms and always double-check the chemical structure alongside any sales reference, especially when the purchase ties into high-value production runs.

Safety & Operational Standards

Working with DMS means dealing with a substance carrying low acute toxicity, but routine chemical safety practices still apply. Skin and eye contact should be avoided, inhalation minimized, and open flames kept away due to modest flammability. Storage calls for cool, ventilated facilities away from strong oxidizers or acids. Material Safety Data Sheets (MSDSs) offer guidance on spill response, disposal, and fire-fighting—each step built around reducing personal risk and avoiding environmental releases. In my work, training crews on personal protective equipment (PPE), spill kits, and ventilation best practices helped avert near misses. Following international standards such as those from OSHA or REACH not only dodges liability issues but protects a business’s greatest asset: its people. Implementing targeted safety protocols often leads to fewer production stoppages and a stronger workplace culture.

Application Area

Polymer chemistry claims DMS as an essential ingredient for plasticizers, film-forming agents, and the backbone for specialty nylons like Nylon 610. It fills a crucial spot in cosmetics and fragrances, where its non-greasy feel and excellent solvency support stable, skin-friendly formulations. DMS appears in some pharmaceutical preparations as a carrier for active ingredients, improving both dispersibility and shelf life. In lubricants, its chemical structure helps develop synthetic ester oils for extreme temperatures, where traditional hydrocarbons falter. Paints, adhesives, and resins draw on DMS for its low volatility and compatibility with diverse resin systems, leading to coatings and sealants that withstand outdoor exposure. Automotive and aerospace sectors invest in DMS derivatives for applications that demand temperature resilience and low migration, from cable insulation to flexible gaskets. Each industry stakes out its own unique requirements, but DMS proves reliable thanks to its versatile backbone and predictable performance.

Research & Development

Modern R&D around DMS zeroes in on greener production routes, advanced polymer blends, and novel biomedical formulations. Scientists put effort into bio-based alternatives for sebacic acid, reducing dependency on petrochemical feedstocks. Work continues on incorporating DMS in biodegradable polymers and next-generation drug carriers, where its compatibility and low-toxicity profile allow for tailored molecular architectures. Universities and consortia target new applications in flexible electronics and renewable energy, pressing for performance characteristics that only DMS-based polyamides or copolymers can offer. I’ve noticed a recent shift toward simulation-driven formulation, with DMS’s properties lending well to these predictive models. Open data and collaborative projects speed up the innovation curve, making progress a team sport between academia and industry. This convergence sparks ideas that push the envelope beyond traditional plastics and coatings into uncharted application spaces.

Toxicity Research

Toxicological studies rate DMS as presenting low acute and chronic risk under normal workplace exposure limits. Studies in rodents and cellular models report negligible carcinogenic or teratogenic effects at typical handling concentrations. Nevertheless, researchers keep digging for long-term bioaccumulation data, especially for industries handling DMS at kilo-ton scale. Environmental toxicology research looks at biodegradability and aquatic toxicity, and DMS displays favorable breakdown profiles, which aligns with eco-friendly design principles. My work intersecting with toxicology teams highlighted that vigilance works both ways: monitoring worker exposure as rigorously as downstream product safety. Regular health checks, workplace monitoring, and stringent housekeeping minimize the risk that rare exposures ever escalate into larger problems.

Future Prospects

The outlook for Dimethyl Sebacate remains strong. Demand from engineered plastics, bio-based polymers, and specialty additives won’t ease as long as industries keep hunting for durability, chemical resilience, and responsible manufacturing. Companies hunt for greener feedstocks and smarter processing to lower environmental footprints and costs simultaneously. The rise of bioplastics, stricter chemical regulations, and high-performance consumer goods all position DMS as a platform molecule with years of innovation ahead. In R&D circles, plans include smart DMS derivatives that respond to light, heat, or electrical signals, expanding into smart packaging, flexible displays, and advanced medical devices. Teams tackle the carbon impact question directly, scouting pathways for circular production and closed-loop recycling. As long as there’s pressure on supply chains and expectations for product performance continue to rise, DMS sits in a rare spot of both stability and untapped potential. New players and established names alike find room to make a mark by pushing DMS into previously unthinkable applications.



What is Dimethyl Sebacate (DMS) used for?

From Science Labs to the Factory Floor

Dimethyl Sebacate, more often called DMS, doesn’t come up often around most kitchen tables. I remember asking a chemist friend what it was, and she compared it to a reliable neighbor: always useful, never flashy. When you start following its trail, especially in manufacturing and chemistry, you realize just how many corners of modern life involve this clear, oily liquid.

How Manufacturers Use DMS

DMS plays a key role as a plasticizer and chemical intermediate. A plasticizer keeps plastics from turning brittle. You see, in the world of synthetic materials, flexibility is gold. If you walk on a soft vinyl floor or handle a cable that bends easily, DMS might have played a quiet part. It slips into polymers like cellulose and certain polyesters and adds enough give that the final product bends instead of breaking. Over time, this helps products last longer.

Beyond making things bendy, DMS often shows up during chemical reactions as a stepping-stone. In making other important chemicals — such as the ingredients found in specialty lubricants, corrosion inhibitors, and lubricating greases — DMS acts a bit like a relay runner passing the baton along. These kinds of lubricants line the gears of precision machines, so a malfunction isn’t just bad luck; it can mean downtime and lost revenue. Reliable raw materials, like DMS, keep entire supply chains humming.

Protecting What Matters

I’ve spoken with folks in the coatings industry, and many recall how DMS found its place in paints and finishes. Products with DMS resist cracking, peeling, and hardening under sunlight or harsh environments. This means longer intervals between repainting and fewer buckets heading to the landfill. I think about this every time I see an old sign that hasn’t faded or chipped; chances are, it owes its toughness to a mix of smart chemistry and substances like DMS.

The Role in Pharmaceuticals and Scents

Inside research labs, DMS pops up in processes for making certain medicines. Its stable chemical structure handles tough reaction conditions without breaking down. This keeps the chemistry moving forward, helping companies deliver consistent results batch after batch. Perfumery takes advantage of DMS as well: it often works as a solvent for sensitive fragrances. It doesn’t mess with the scent and evaporates at just the right pace, making it handy for both high-end perfume makers and industrial air fresheners. A nose for quality sometimes relies on chemicals doing their job quietly.

Focusing on Safety and Sustainability

Using DMS comes with responsibility. Handling any industrial chemical, even relatively low-toxicity ones like DMS, asks for care and proper equipment. Over the years, regulations have grown meant to protect workers and the environment. Companies have started looking at bio-based sources of sebacic acid — the stuff DMS is made from — giving farmers and green tech innovators a bigger role. Cleaner processes and tight recycling loops reduce the risk of contamination and waste.

Looking to the Future

People rarely cheer for specialty chemicals, but they shape much more of the modern world than most realize. Products last longer, factories run smoother, and goods stay safer during shipping. As more industries push for sustainable solutions, DMS’s steady performance and flexible chemistry might offer a stepping-stone toward better materials that don’t trade safety for convenience. As someone who values products that work and last, I look forward to seeing how smarter chemistry, using old standbys like DMS, builds a greener future.

What are the physical and chemical properties of Dimethyl Sebacate?

What It Looks Like and How It Behaves

Dimethyl sebacate catches the eye as a clear, colorless liquid. It doesn’t demand attention with a strong smell—its faint floral scent makes it easy to work around in the lab or factory. This liquid boils at about 260°C and solidifies just above freezing, around -1°C, which means it flows easily at standard temperatures but won’t vaporize unless things get quite hot. Science points to its density falling close to 1.06 g/cm³. Mix it with a lot of the usual suspects like alcohols, esters, and ethers and it blends in well. Water keeps its distance, though: dimethyl sebacate barely dissolves in it. That speaks volumes to chemists or anyone wanting to clean it up or separate it after a reaction.

Chemical Stability and Reactivity

This compound falls under the ester family, born from sebacic acid and methanol. In my lab years, keeping esters like this away from moisture and strong acids or bases cut down on unwanted reactions. Old bottles might start to smell faintly of carboxylic acid if left open for too long—hydrolysis starts to creep in, breaking it down. Acids or bases speed up that breakdown, which lines up with the experience of anyone who’s ever wanted to recycle or destroy it safely. That chemical stubbornness makes it reliable for a lot of production lines. For most storage and daily use, it keeps to itself unless provoked.

Real-World Utility

People use dimethyl sebacate to make plasticizers, which means it softens up plastics for things like flexible tubing or adhesives. It’s a go-to for synthetic lubricants, too, because it handles both heat and cold without losing its flow or turning gummy. The perfume world also finds value in it as a carrier, thanks to its neutrality and gentle scent. It sees real action in coatings and films, helping resins level out and spread without unwanted reactions. My old team once tried it as a solvent in a small-batch experiment; cleanup became quick due to its poor affinity for water, making post-process separation almost routine.

Safety and Environmental Concerns

Dimethyl sebacate rarely acts as a troublemaker in terms of acute health effects. Splash some on your skin and nothing much happens right away, though protective gloves are still part of the toolkit. Breathing in vapor doesn’t usually create much risk, but good ventilation never hurts. Plants and animals handle small spills fairly well, as environmental breakdown happens in reasonable timeframes. Still, improper disposal—or huge leaks—could stress waterways, especially since it floats on water and can coat surfaces. Facilities must remain mindful of how waste gets handled, supporting the idea that green chemistry isn’t just a trend but a necessity.

Improving Handling and Use

In the real world, small changes go a long way. Handling this compound with automated pumps rather than open pours, for example, cuts workers’ exposure and keeps surfaces clean. Investing in closed-system distillation recycles leftover material and lowers costs—something our chemical plant embraced with good results. Keeping better spill response kits handy, focused on absorbents that target esters, helps pull dimethyl sebacate out of water faster. Regulatory improvements mean more facilities look at life-cycle impacts, not just immediate risks, supporting both community health and long-term sustainability across the supply chain.

Is Dimethyl Sebacate hazardous or toxic?

Understanding Dimethyl Sebacate

Dimethyl sebacate turns up in plenty of places – from the plastics used in home décor to lubricants and cosmetics. Chemically, it’s a colorless liquid, and its main job involves acting as a plasticizer or solvent. This chemical rarely crosses most people’s minds, but for anyone working in manufacturing or handling products at home, questions about safety come up pretty quickly.

The Real Risks in Everyday Use

I’ve handled industrial chemicals in past work, and manufacturers almost always focus on keeping workers safe, not just making the end product look good. Dimethyl sebacate doesn’t top the list of highly-dangerous substances. It won’t eat through skin like strong acids or knock you out like some volatile solvents. Most health agencies rate its acute toxicity as low. That doesn’t mean it gets a free pass. Long hours in a workplace with poor ventilation, especially handling any chemical, invite health problems that build over time. Breathing in its fumes in large amounts or handling it carelessly could lead to headaches, nausea, or skin irritation.

The bigger story here involves what happens in manufacturing plants where safety practices sometimes get skipped over. Without gloves or goggles, direct skin and eye contact causes irritation. Inhaling higher concentrations, especially where fumes build up in workshops or labs, affects breathing and mood, which lines up with countless occupational health studies. Companies with responsible safety protocols—good airflow, gloves, goggles—usually have little cause for worry.

Long-Term Implications: Myth vs. Fact

Many people see words like “ester compound” and expect hidden dangers. It’s smart to stay skeptical. Here’s what matters: Dimethyl sebacate doesn’t accumulate in the body the way dangerous heavy metals or certain pesticides do. The U.S. Environmental Protection Agency and similar organizations in Europe haven’t labeled it as carcinogenic or a cause of birth defects. It breaks down in the environment faster than more infamous plasticizers such as phthalates.

On the topic of environmental impact, waste management remains a sticking point. Pouring this liquid down the drain sends it into water systems, where it doesn’t last as long as tougher chemicals but could still harm aquatic creatures if dumped in huge quantities. Industrial settings, especially in countries with relaxed environmental laws, create bigger risks. As urban residents, we can push for better waste treatment and support companies that publish clear safety data.

Practical Steps for Workers and Consumers

Factories and labs owe it to workers—people like me, my family, my friends—to put safety gear at every workstation. I’ve seen companies cut corners with training or safety materials to save costs, and the results always end badly, from rashes to ER visits. Regular training, proper labeling, and emergency eyewash stations turn near-misses into non-events.

Consumers worried about products containing this chemical should check for up-to-date product safety data sheets. Look for transparency and clear ingredient lists. Governments can require honest labeling and force manufacturers to share legitimate safety information.

Finding Balance in Chemical Safety

Dimethyl sebacate doesn’t deserve a spot among the world’s nastiest chemicals, but treating any chemical as completely harmless creates new risks. People need reliable information, protective equipment, and accountability from those controlling the supply chain. Building better habits—like reading labels and demanding clear safety data—means fewer nasty surprises, both today and down the road.

How should Dimethyl Sebacate be stored and handled?

Understanding the Risks

Dimethyl sebacate works its way into many processes, especially in making plastics and lubricants. It carries a mild scent and slips around as an oily liquid. It looks harmless, but people who spend time with it know to respect its quirks. The liquid evaporates if left alone with air and doesn’t always sit well inside a warm or damp building. Room for mistakes shrinks as soon as leaks or spills start happening: skin gets irritated, fumes build up, the risk of a fire sneaks in. One slip and burns or headaches can become real problems—no workplace gains from ignoring those facts.

Keeping Storage Simple and Solid

I once visited a plant where stocked drums of this chemical stood right next to open sunlight. Sweat formed on the containers and the smell in the air ratcheted up with the heat. Nobody felt comfortable, especially those moving stock day after day. After a run of odd symptoms and a few panicked moments over a sticky floor, management demanded action: storage shifted to shaded rooms, away from sources of heat or flames. Temperatures leveled off. Less time spent on mopping up, fewer complaints.

Companies avoid headaches by choosing steel containers with tight-fitting lids. Plastic may crack, so stick with sturdy metal. The storage room runs cool, dry, and well-ventilated—think less about showy comfort, more about peace of mind. Warehouses with a spark risk, even from simple switches, are no fit for this chemical. Simple lockers do the trick if access feels too open. Labels in big, bold letters leave no room for “I didn’t know what it was.”

Fires pose a real threat. Flammable liquids want distance from careless sources. I’ve seen folks outfit storerooms with foam extinguishers and sand buckets; it is not overkill, it’s smart insurance. Keep absorbent supplies handy; the day they’re needed always feels sudden but never regrettable. Save the drama for somewhere else.

Handling Without Drama

Every move with dimethyl sebacate starts with personal protection. Gloves and goggles aren’t for show. Uncovered skin itches, and harsh fumes attack without warning. In one smaller packaging shop, a new worker handled a tiny spill bare-handed—he thought it’d just wipe clear. The rash that showed up before noon convinced him otherwise. Clean-up kits, clear walkthroughs, and friendly buddy checks build a routine that beats bad surprises. Sharing stories about what’s happened before—good and bad—turns theories into lessons learned.

Never pour this chemical into drains. I once saw a shortcut planned: one call to the waste company shut that down for good. Regulations come with steep penalties, and nobody wins when a river downstream runs slick. Always seal containers after use. If a spill breaks out, reach for absorbent pads or sand before jumping toward water hoses—the goal is to pause harm, not spread it.

Building a Safety Culture

Real care means more than instructions taped to a wall. Training slips into regular routines. Reinforce safety with checklists and shared stories in break rooms. Supervisors model habits, newcomers get reminders, and everyone stays quick on their feet. Fact sheets and emergency contacts hang by the door, not hidden away in a drawer.

People who work together build up a sixth sense for risk. By swapping shortcuts for solid practice, crews watch out for each other. Mistakes shrink, confidence grows. Trust comes from consistency, not luck or guesswork. Nobody has to face trouble solo.

What industries commonly use Dimethyl Sebacate?

The Backbone of Certain Plastics

Factories making flexible plastics keep dimethyl sebacate on hand for a reason—it’s more than just some obscure chemical. Turn to plasticizers and you’ll find this ester helping soften PVC, polyethylene, and other polymers. Shoe soles, wire coatings, and tubing feel softer and last longer with it in the mix. Way back when I worked with an art supply manufacturer, many modeling clays and erasers shined brighter with ingredients like dimethyl sebacate; they just didn’t dry out as fast. Flexible plastics turn up in homes, hospitals, and cars, so products with dimethyl sebacate stretch far beyond the chemistry lab.

Pharmaceuticals Looking for the Right Touch

Pharmaceuticals don’t always hit the headlines for what goes inside the pill—not the active ingredient, but what keeps the pill together. Solution developers appreciate dimethyl sebacate for its solvency and stability. Enteric coatings on tablets, delay-release capsules, and even medical ointments all benefit from the gentle action of this compound. Some folks remember the “inactives” in prescription bottles mainly for allergies, but trust me, without a reliable and neutral carrier for vital drugs, effectiveness drops.

Cosmetics and Personal Care

Anyone stocking lotions or sunscreen sees the ingredient lists filled with long chemical names. Dimethyl sebacate sneaks into skin creams, perfumes, and hair products, giving them a lighter texture and helping fragrances last. In my own home, my kid’s eczema cream felt oily until we found a formula using this ester—less greasy, more absorbent, and no rashes. Beauty chemists know a smooth lotion or personal spray owes part of its magic to such gentle carriers.

The Lubricant and Automotive Fields

People don’t talk about all the work synthetic lubricants do behind the scenes. Gearbox oils and engine fluids keep moving parts cool and working smoothly. Blenders use dimethyl sebacate to shape the viscosity, so when cars run through summer heat or bitter cold, their lubrication performs consistently. In workshops I’ve visited, mechanics look for consistency and protection in their oils—seeing dimethyl sebacate on the technical sheet signals longer life and less corrosion on customer engines.

Flavor and Fragrance Creation

The world of food additives and scents depends on stable, clean-tasting intermediates. Dimethyl sebacate offers a blank canvas when chemists mix up flavors for candies or extracts for personal care products. I once toured a flavor house, and the chemist pointed out that just a trace of the wrong solvent could ruin an entire batch of strawberry essence or orange extract. Using dimethyl sebacate, they kept the final taste pure and the aroma intact, vital for companies trusting those flavors to draw in loyal buyers.

Sustainable Manufacturing and the Environmental Challenge

Demand for biodegradable plastics and greener lubricants puts dimethyl sebacate in the spotlight for modern companies trying to tread lightly on the planet. It comes from sebacic acid, which often traces back to castor oil—a renewable resource. I’ve spoken with product designers searching for plant-based and less-toxic ingredients and they see dimethyl sebacate as a stepping stone toward safer end results. Still, scaling up renewable chemical sourcing and cutting down industrial waste takes real investment and planning.

Moving Toward Safer Use

Workers in factories and labs handling dimethyl sebacate follow strict safety guidelines—gloves, seals, and air filters. Exposure over time could irritate skin or eyes, so training and safe storage limit risks. Companies keep safety data on hand and teach it to new hires. Better monitoring and process improvements ease old worries about spills, air quality, and health problems. Regular audits help spot gaps before they harm anyone.

Final Thoughts

Dimethyl sebacate might not headline most news feeds, but it plays an essential role in flexible plastics, pharmaceuticals, cosmetics, lubricants, and food technology. As sustainability takes a larger role in supply chains, more producers look for ways to keep benefits while reducing environmental cost. Solutions may come from bio-based production, tighter controls, and smarter chemical engineering—showing this under-the-radar compound is here to stay.

Dimethyl Sebacate(DMS)
Names
Preferred IUPAC name Dimethyl decanedioate
Other names Sebacic acid dimethyl ester
Dimethyl decanedioate
Decanedioic acid dimethyl ester
Pronunciation /daɪˈmiːθəl sɪˈbeɪkət/
Identifiers
CAS Number 106-79-6
Beilstein Reference 1462536
ChEBI CHEBI:39136
ChEMBL CHEMBL3184978
ChemSpider 11450
DrugBank DB14189
ECHA InfoCard 100.010.251
EC Number 204-558-8
Gmelin Reference 131207
KEGG C19699
MeSH D000066237
PubChem CID 8431
RTECS number AJ3675000
UNII 2ZQ4N544NG
UN number UN2264
Properties
Chemical formula C12H22O4
Molar mass 258.38 g/mol
Appearance Colorless transparent liquid
Odor Mild
Density 1.06 g/cm³
Solubility in water Slightly soluble
log P 3.89
Vapor pressure 0.02 mmHg (25°C)
Acidity (pKa) ~25 (as an ester, typical pKa of alpha-hydrogens)
Basicity (pKb) 6.9
Magnetic susceptibility (χ) -6.53×10⁻⁶ cm³/mol
Refractive index (nD) 1.4230
Viscosity 2.92 cP at 25°C
Dipole moment 4.62 D
Thermochemistry
Std molar entropy (S⦵298) 352.7 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -726.3 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -6766 kJ/mol
Pharmacology
ATC code D04AA21
Hazards
GHS labelling GHS02, GHS07
Pictograms GHS07,GHS09
Signal word Warning
Hazard statements H317, H319
Precautionary statements P210, P280, P305+P351+P338, P337+P313
NFPA 704 (fire diamond) 1-1-0
Flash point 127°C (closed cup)
Autoignition temperature 400 °C
Explosive limits Explosive limits: 0.7–7.9%
Lethal dose or concentration LD50 (oral, rat): 8200 mg/kg
LD50 (median dose) LD50 (median dose): 8200 mg/kg (rat, oral)
NIOSH WA1725000
PEL (Permissible) Not established
REL (Recommended) 300 mg/m³
Related compounds
Related compounds Sebacic acid
Diethyl sebacate
Dibutyl sebacate