Product Name: 2-(4-Bromomethyl)Phenylpropionic Acid
Synonyms: BMPPA, 4-(Bromomethyl)-α-methylbenzeneacetic acid
CAS Number: 99918-43-1
Manufacturer: [Company Name or Supplier – to be filled in as necessary]
Recommended Uses: Intermediate in organic synthesis and pharmaceutical development
Restrictions on Use: Industrial or research use only, not for food, drug, household, or cosmetic applications, avoid non-professional handling
Emergency Contact: [Insert emergency phone number for rapid spill or exposure response]
Classification: Acute Toxicity (Oral, Inhalation, Dermal); Skin and eye irritant; Possible reproductive hazard
Label Elements: Danger pictogram, signal word: Danger; hazard statements include fatal if swallowed, toxic in contact with skin or if inhaled, causes severe skin burns and eye damage
Precautionary Statements: Do not breathe dust or fumes, use in ventilated area, wash hands thoroughly after handling, wear protective gear, avoid release to the environment
Hazards Not Otherwise Classified: Contact with acids may generate toxic gases, fine particulate may combust in specific conditions
Chemical Name: 2-(4-Bromomethyl)Phenylpropionic Acid
Formula: C10H11BrO2
Molecular Weight: 243.10 g/mol
Concentration: ≥99% by weight
Impurities/Stabilizers: Trace solvents from synthesis (≤0.01%), no added preservatives
Other Components: None reported by supplier
Inhalation: Remove person to fresh air, keep at rest, provide oxygen if breathing is difficult, seek medical advice rapidly
Skin Contact: Remove contaminated clothing, rinse affected area with plenty of water for at least 15 minutes, clean area with soap, seek medical support for irritation or burns
Eye Contact: Flush eyes thoroughly with clean water for a minimum of 15 minutes, avoid rubbing, keep eyelids open, seek immediate medical attention
Ingestion: Rinse mouth thoroughly, never induce vomiting, do not give anything by mouth to an unconscious individual, seek medical care or poison control support without delay
Most Important Symptoms and Effects: Irritation, chemical burns, respiratory distress, possible CNS depression
Advice for Physician: Provide symptomatic treatment, consider possible delayed absorption due to slow hydrolysis
Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, water spray (do not use direct water stream on burning product)
Specific Hazards: High temperature decomposition may emit corrosive fumes like HBr, CO2, CO; dust may form explosive mixture with air in certain conditions
Special Protective Equipment: Firefighters require self-contained breathing apparatus and complete protective clothing, advance with extreme caution
Firefighting Advice: Evacuate area, avoid inhaling fumes, contain runoff to prevent contamination of water sources, cool containers with water mist if safe to do so
Personal Precautions: Evacuate non-essential personnel, avoid contact with skin or eyes, ventilate area, prevent inhalation of dust or fumes
Protective Equipment: Wear chemical splash goggles, nitrile gloves, full-body covering, and approved respirator for dusty conditions
Environmental Precautions: Prevent material from reaching drains or open waterways, inform appropriate authorities of larger spills or releases
Cleanup Methods: Collect spillage mechanically without generating dust, place residue in sealed containers, clean area with detergent, ventilate thoroughly after cleanup
Disposal: Dispose of contaminated materials and cleanup residue in accordance with local, regional, and national hazardous waste regulations
Safe Handling: Handle only in closed equipment or systems, avoid breathing dust or vapors, prevent skin contact, wash hands before breaks and after handling, avoid eating or smoking in work areas
Storage Conditions: Store in tightly sealed original packaging, in dry, ventilated, and cool conditions, away from heat, direct sunlight, oxidizing and acidic materials
Packaging Materials: Use corrosion-resistant, sealed containers, label all containers clearly with product name and hazard warnings
Incompatible Materials: Strong acids, strong oxidizers, amines, reducing agents
Special Requirements: Keep far from sources of ignition, avoid static discharge, do not store above 25°C for extended periods, periodic inspection of containers
Exposure Limits: No OSHA, ACGIH, NIOSH TLV established; limit exposure based on best industrial hygiene judgment
Engineering Controls: Use process enclosures, local exhaust ventilation, and dust collection to keep airborne concentrations below recommended limits
Personal Protective Equipment: Chemical goggles, face shield, nitrile gloves, laboratory coat or chemical-resistant apron, approved particulate respirator in case of dust generation
Hygiene Measures: Change contaminated clothing promptly, wash hands thoroughly, clean work surfaces after handling
Monitoring Methods: Air monitoring for particulates can be done using gravimetric sampling or personal badges suitable for fine dust detection
Other Precautions: Use only with appropriate access controls and trained staff, maintain eyewash stations and emergency showers at site
Appearance: Off-white to light beige crystalline powder
Odor: Slightly aromatic, faint medicinal odor
Odor Threshold: Not established
pH (1% solution): Slightly acidic, 3.5 – 4.5
Melting Point: 120–124°C
Boiling Point: Decomposes before boiling
Flash Point: ~110°C (closed cup, estimated)
Flammability: May be combustible as powder
Vapor Pressure: Not measurable at room temperatures
Solubility: Slightly soluble in water, more soluble in acetone, methanol, ethanol, ethyl acetate
Partition Coefficient (log Kow): Estimated 2.5–3.2
Auto-Ignition Temperature: No data
Decomposition Temperature: ~130°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under normal storage and handling conditions
Possibility of Hazardous Reactions: Hazardous polymerization does not occur under ambient conditions
Conditions to Avoid: High humidity, heating above 130°C, sources of ignition, direct sunlight
Incompatible Materials: Strong acids, oxidizing agents, reducing substances
Decomposition Products: Bromine compounds (HBr), carbon monoxide, carbon dioxide, benzyl or propionic acid derivatives; can be hazardous if inhaled
Acute Toxicity: Based on structural similarity, anticipated oral LD50 rat: 350–800 mg/kg; can cause nausea, drowsiness, convulsions if ingested
Irritation/Corrosion: Causes severe skin and eye irritation or burns, may cause respiratory tract irritation
Chronic Effects: No chronic exposure data, repeated contact may cause dermatitis or sensitization
Sensitization: No data provided, but risk expected based on structure
Mutagenicity: Not tested, chemical class may cause concern
Reproductive Toxicity: Not evaluated, use with caution in reproductive-age individuals
Other Information: Systemic absorption can lead to CNS depression, headaches, and coordinated movement impairment
Ecotoxicity: Harmful to aquatic organisms, may cause long-lasting effects in aquatic environments
Mobility in Soil: Moderately mobile, risk of groundwater contamination if released
Persistence/Degradability: Expected to degrade slowly, not readily biodegradable
Bioaccumulation: Possible based on moderate log Kow
Other Adverse Effects: No evidence of significant photodegradation, accumulates in sediment, careful oversight of emissions into water recommended
Disposal Methods: Dispose in accordance with local, state, and federal regulations, utilize hazardous waste incineration or chemical treatment preferred
Contaminated Packaging: Destroy empty containers using approved hazardous methods, do not reuse packaging
Special Precautions: Do not release to sewer, surface water, or soil, prevent direct exposure of wildlife
Waste Codes: Refer to federal, state, or local listings relevant to halogenated organic acids
Disposal Advice: Collaborate with licensed hazardous waste disposal services with documented chain-of-custody
UN Number: 3261 (Corrosive solid, acidic, organic, n.o.s — for this substance as typically assigned)
UN Proper Shipping Name: Corrosive solid, acidic, organic, n.o.s. (contains 2-(4-Bromomethyl)phenylpropionic acid)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II (Medium danger)
Marine Pollutant: Yes
Special Transport Measures: Protect containers from movement, report leakage immediately during transit, keep manifest and hazard communication available for all handlers
Regulatory Transport Labels: Corrosive, Marine Pollutant marks as dictated by shipment route
U.S. TSCA: Not listed for specific commercial production, R&D use under appropriate exemption advised
EINECS/ELINCS: Not present as of latest update, restricted for industrial/laboratory uses
SARA Section 302/304/313 Notification: Not explicitly listed, but brominated organics often subject to reporting
California Prop 65: Not individually listed, but chemical class brings potential reproductive hazard scrutiny
Other National Regulations: Handle per regional chemical safety laws, may require reporting as hazardous under country-specific right-to-know regulations
Labeling Requirements: Display GHS Danger label, with signal word, hazard pictograms, and detailed risk and precaution statements
Training: Personnel must be trained in handling, first aid, accidental release, and emergency procedures; annual review encouraged
